**Previous Episode: [[BDE327]]** **Next Episode: [[BDE329]]** %%Post image thumbnail below.%%  > [!abstract|no-i] **Episode Overview** **Date Aired:** [[06-05-2024]] **Title:** Not So First Ever **Episode:** 328 **Description:** Did you know the H5N2 bird flu in Mexico is different from the H5N1 HA elsewhere? Did you know there were investigations on H5N2 ten years ago? Did you know it was associated with flu vaccines? **Link:** https://rumble.com/v501ug6-big-dig-energy-328-not-so-first-ever.html %%<https://historydraft.com/happened/what-happened/1-January/world>%% ## Replay %% Get embed URL then highlight and hit ALT + I%% <iframe src="https://rumble.com/embed/v4xpl50/?pub=6eeyh" allow="fullscreen" allowfullscreen="" style="height:100%;width:100%; aspect-ratio: 16 / 9; "></iframe> <br> ## Greetings & Announcements 1. I will be on Simpcast this Sunday. ## Segments ### Mental Models I've added a new section to the BDE website called Mind Mapping in the toolbox. I've added a page [Using Frameworks to Dig](https://www.bigdigenergy.info/dig-frameworks) to start it off. It's centered on frameworks and mental models you can use to help examine different aspects of a topic that you might not have otherwise considered. Y'all have asked me a few times to create classes and how-tos on how to do what I do, and I've heard you. I've moved forward on it slowly, because usually any time someone is trying to sell you a class on something, they're full of shit. (Not that I would sell access, but still.) But this is a start, and it's one that is actually helpful. I reference my own personal mental modeling notes all the time. ### Bird Flu #### H5N2 On Wednesday (yesterday, 06-05-2024), the [[World Health Organization]] reported the "first confirmed" human case of the H5N2 type of bird flu in a 59-year-old man in Mexico who died in April. The strain is different from the outbreak of bird flu virus, called [[H5N1]], that is circulating among herds of dairy cows in the United States and has said to have caused mild infection among three farmworkers. The [WHO Announcement](https://archive.ph/C5FwH):  > On 23 May 2024, the Mexico International Health Regulations (IHR) National Focal Point (NFP) reported to PAHO/WHO a confirmed fatal case of human infection with avian influenza A(H5N2) virus detected in a resident of the State of Mexico who was hospitalized in Mexico City. This is the first laboratory-confirmed human case of infection with an influenza A(H5N2) virus reported globally and the first avian H5 virus infection in a person reported in Mexico. Although the source of exposure to the virus in this case is currently unknown, A(H5N2) viruses have been reported in poultry in Mexico. According to the IHR (2005), a human infection caused by a novel influenza A virus subtype is an event that has the potential for high public health impact and must be notified to the WHO. Based on available information, WHO assesses the current risk to the general population posed by this virus as low. > > **Description of the situation** > > On 23 May 2024, the Mexico IHR NFP reported to PAHO/WHO a confirmed case of human infection with avian influenza A(H5N2) virus detected in a 59-year-old resident of the State of Mexico who was hospitalized in Mexico City and had no history of exposure to poultry or other animals. **The case had multiple underlying medical conditions**. The case's relatives reported that the case had already been **bedridden for three weeks, for other reasons, prior to the onset of acute symptoms.** > > On 17 April, the case developed fever, shortness of breath, diarrhoea, nausea and general malaise. On 24 April, the case sought medical attention, was hospitalized at the National Institute of Respiratory Diseases "Ismael Cosio Villegas" (INER per its acronym in Spanish) and died the same day due to complications of his condition. > > **Results from Real-Time Polymerase Chain Reaction (RT-PCR) of a respiratory sample collected and tested at INER on 24 April indicated a non-subtypeable influenza A virus**. On 8 May, the sample was sent for sequencing to the Laboratory of Molecular Biology of Emerging Diseases Center for Research in Infectious Diseases (CIENI per its acronym in Spanish) of INER, which indicated that the sample was positive for influenza A(H5N2). On 20 May, the sample was received at the Institute of Epidemiological Diagnosis and Reference (InDRE per its acronym in Spanish) of the Mexico National Influenza Centre, for analysis by RT-PCR, obtaining a positive result for influenza A. On 22 May, sequencing of the sample confirmed the influenza subtype was A(H5N2). > > No further cases were reported during the epidemiological investigation. Of the 17 contacts identified and monitored at the hospital where the case died, one reported a runny nose between 28 and 29 April. Samples taken from these hospital contacts between 27 and 29 May tested negative for influenza and [[SARS]]-CoV 2. **Twelve additional contacts (seven symptomatic and five asymptomatic) were identified near the case's residence.** Samples of pharyngeal exudate, nasopharyngeal swabs and serum were obtained from these individuals. On 28 May, the InDRE reported that all twelve samples from contacts near the patient's residence tested negative for SARS-CoV-2, influenza A and influenza B, as determined by RT-PCR. **The results of the serological samples are pending.** He was morbidly obese, acquired type 2 diabetes, was confined to a bed, and had complete kidney failure. None of it was related to "bird flu." ##### Not so First Ever Letter to the Editor: [Human H5N2 bird flu infection: fact or fallacy?](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025352/#b6)  --- [Serological survey of avian H5N2-subtype influenza virus infections in human populations](https://pubmed.ncbi.nlm.nih.gov/19189196/)  Full Text: https://sci-hub.se/10.1007/s00705-009-0319-7 --- [Human H5N2 avian influenza infection in Japan and the factors associated with high H5N2-neutralizing antibody titer](https://pubmed.ncbi.nlm.nih.gov/18603824/) Conclusion: The results suggest that this may have been the first avian influenza H5N2 infection of poultry to affect humans. A history of seasonal influenza vaccination might be associated with H5N2-neutralizing antibody positivity. #### H5N1 Deborah Birx proposes weekly testing for every cow in America to stop bird flu. <iframe title="Why America could fail again: Dr. Birx's stark pandemic warning" src="https://www.youtube.com/embed/9Uw5UTTXmAg?start=360&amp;feature=oembed" height="113" width="200" style="aspect-ratio: 1.78041 / 1; width: 100%; height: 100%;" allowfullscreen="" allow="fullscreen"></iframe> [Deborah Birx proposes weekly testing for every cow in America to stop bird flu](https://www.dossier.today/p/deborah-birx-proposes-weekly-testing) [My Tweet](https://twitter.com/SomeBitchIIKnow/status/1798375150439792816)  [H5 influenza wastewater dashboard launches | CIDRAP](https://www.cidrap.umn.edu/avian-influenza-bird-flu/h5-influenza-wastewater-dashboard-launches) [H5N1 bird flu detected in SF, first in California city wastewater](https://www.sfchronicle.com/health/article/h5n1-avian-flu-san-francisco-19489217.php) [WastewaterSCAN Dashboard](https://data.wastewaterscan.org/) %%Footer Starts Here%% --- <center><img src="https://archive.is/do5ay/df25cfff93575f174c387ac9f4c64744da0fadb9.png" alt="Keep digging!" height="100px"></center> --- ## Tags ### Linked Pages & Footnotes